Supplementary Material for: Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli
نویسندگان
چکیده
1 Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel. 2 Department of Biological Regulation, Weizmann Institute of Science,Rehovot, Israel. 3 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel. 4 Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. 5 Sheba Cancer Research Center, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 6 These authors contributed equally to this work. 7 Present address: Department of Medicine 1 & Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. ∗ Corresponding authors.
منابع مشابه
Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli
Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide measurements demonstrate that genes with similar mRNA profiles often exhibit marked differences ...
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